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1

Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors

Hanisak, Jennifer, Michael Seganish, W., McElroy, William T., Tang, Haiquin, Zhang, Rui, Tsui, Hon-Chung, Fischmann, Theirry, Tulshian, Deen, Tata, James, Sondey, Christopher, Devito, Kristine, Fosset

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 777 KB

english, 2016

2

The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): Comparison of efficacy and side effects across rodent species

Sherry X. Lu, Guy A. Higgins, Robert A. Hodgson, Lynn A. Hyde, Robert A. Del Vecchio, Donald H. Guthrie, Tatiana Kazdoba, Martha F. McCool, Cynthia A. Morgan, Ana Bercovici, Ginny D. Ho, Deen Tulshian

Journal:

European Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 602 KB

english, 2011

3

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation

McElroy, William T., Tan, Zheng, Ho, Ginny, Paliwal, Sunil, Li, Guoqing, Seganish, W. Michael, Tulshian, Deen, Tata, James, Fischmann, Thierry O., Sondey, Christopher, Bian, Hong, Bober, Loretta, Jack

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.00 MB

english, 2015

4

Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors

Seganish, W. Michael, Fischmann, Thierry O., Sherborne, Brad, Matasi, Julius, Lavey, Brian, McElroy, William T., Tulshian, Deen, Tata, James, Sondey, Christopher, Garlisi, Charles G., Devito, Kristine

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 5.27 MB

english, 2015

5

The Discovery and Synthesis of Novel Adenosine Receptor (A2A) Antagonists.

Julius J. Matasi, John P. Caldwell, Jinsong Hao, Bernard Neustadt, Leyla Arik, Carolyn J. Foster, Jean Lachowicz, Deen B. Tulshian

Journal:

Year:

2005

File:

PDF, 21 KB

2005

6

2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine Analogues: Highly Potent, Orally Active, Adenosine A2A Antagonists. Part 1.

Julius J. Matasi, John P. Caldwell, Hongtao Zhang, Ahmad Fawzi, Mary E. Cohen-Williams, Geoffrey B. Varty, Deen B. Tulshian

Journal:

Year:

2006

File:

PDF, 22 KB

2006

7

2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine Analogues as Adenosine A2A Antagonists: The Successful Reduction of hERG Activity. Part 2.

Julius J. Matasi, John P. Caldwell, Hongtao Zhang, Ahmad Fawzi, Guy A. Higgins, Mary E. Cohen-Williams, Geoffrey B. Varty, Deen B. Tulshian

Journal:

Year:

2006

File:

PDF, 12 KB

2006

8

Synthesis and structure–activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands

John P. Caldwell, Julius J. Matasi, Hongtao Zhang, Ahmad Fawzi, Deen B. Tulshian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 127 KB

english, 2007

9

Synthesis and structure–activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1

Ginny D. Ho, Ana Bercovici, Deen Tulshian, William J. Greenlee, Ahmad Fawzi, April Smith Torhan, Hongtao Zhang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 138 KB

english, 2007

10

The discovery and synthesis of novel adenosine receptor (A2A) antagonists

Julius J. Matasi, John P. Caldwell, Jinsong Hao, Bernard Neustadt, Leyla Arik, Carolyn J. Foster, Jean Lachowicz, Deen B. Tulshian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 122 KB

english, 2005

11

6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists

Eugenia Kiselgof, Deen B. Tulshian, Leyla Arik, Hongtao Zhang, Ahmad Fawzi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 120 KB

english, 2005

12

2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs as adenosine A2A antagonists: The successful reduction of hERG activity. Part 2

Julius J. Matasi, John P. Caldwell, Hongtao Zhang, Ahmad Fawzi, Guy A. Higgins, Mary E. Cohen-Williams, Geoffrey B. Varty, Deen B. Tulshian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 161 KB

english, 2005

13

2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: Highly potent, orally active, adenosine A2A antagonists. Part 1

Julius J. Matasi, John P. Caldwell, Hongtao Zhang, Ahmad Fawzi, Mary E. Cohen-Williams, Geoffrey B. Varty, Deen B. Tulshian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 170 KB

english, 2005

14

3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists

Lisa S. Silverman, John P. Caldwell, William J. Greenlee, Eugenia Kiselgof, Julius J. Matasi, Deen B. Tulshian, Leyla Arik, Carolyn Foster, Rosalia Bertorelli, Angela Monopoli, Ennio Ongini

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 167 KB

english, 2007

15

Synthesis and structure–activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2

Ginny D. Ho, Ana Bercovici, Deen Tulshian, William J. Greenlee, Ahmad Fawzi, Xiomara Fernandez, Robbie L. McLeod, April Smith Torhan, Hongtao Zhang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 252 KB

english, 2007

16

Structure–activity relationships of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the treatment of cough

Shu-Wei Yang, Ginny Ho, Deen Tulshian, William J. Greenlee, Xiomara Fernandez, Robbie L. McLeod, Stephen Eckel, John Anthes

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 186 KB

english, 2008

17

Synthesis and structure–activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: Part 2

John P. Caldwell, Julius J. Matasi, Xiomara Fernandez, Robbie L. McLeod, Hongtao Zhang, Ahmad Fawzi, Deen B. Tulshian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 699 KB

english, 2009

18

Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety

Shu-Wei Yang, Ginny Ho, Deen Tulshian, William J. Greenlee, Zheng Tan, Hongtao Zhang, April Smith-Torhan, Ahmad Fawzi, John Anthes, Sherry Lu, Geoffrey Varty, Xiomara Fernandez, Robbie L. McLeod, John

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 897 KB

english, 2009

19

Structure–activity relationships of 2,4-diphenyl-1H-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain

Shu-Wei Yang, Jennifer Smotryski, Julius Matasi, Ginny Ho, Deen Tulshian, William J. Greenlee, Rossella Brusa, Massimiliano Beltramo, Kathleen Cox

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.66 MB

english, 2011

20

Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: Part 1

Julius J. Matasi, Stephanie Brumfield, Deen Tulshian, Michael Czarnecki, William Greenlee, Charles G. Garlisi, Hongchen Qiu, Kristine Devito, Shu-Cheng Chen, Youngliang Sun, Rosalia Bertorelli, Willia

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.42 MB

english, 2011

21

Studies directed at the synthesis of verrucarol from D-glucose: the A-B moiety

Deen Bhandu Tulshian, Bert Fraser-Reid

Journal:

Year:

1984

Language:

english

File:

PDF, 560 KB

english, 1984

22

The ready conversion of anguidine into verrucarol and trichodermol

Deen Bandhu Tulshian, Bert Fraser-Reid

Journal:

Tetrahedron Letters

Year:

1980

Language:

english

File:

PDF, 190 KB

english, 1980

23

Striking contrasts in stereoselectivities of spiro-claisen rearrangements of pyranosides versus carbocycles.

Bert Fraser-Reid, Deen B. Tulshian, Ray Tsang, Derek Lowe, Vernon G.S. Box

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 302 KB

english, 1984

24

Synthesis of a catechol metabolite of dilevalol

Deen B Tulshian, A Bercovici

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 189 KB

english, 1993

25

Versatile synthesis of dihydroxy γ and δ amino acids from carbohydrates

D.B. Tulshian, A.F. Gundes, M. Czarniecki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 299 KB

english, 1992

26

Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors

Ginny Dai Ho, Silverman Lisa, Ana Bercovici, Chester Puchalski, Deen Tulshian, Yan Xia, Michael Czarniecki, Michael Green, Renee Cleven, Hongtao Zhang, Ahmad Fawzi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 260 KB

english, 1999

27

Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

G. B. Varty, L. A. Hyde, R. A. Hodgson, S. X. Lu, M. F. McCool, T. M. Kazdoba, R. A. Del Vecchio, D. H. Guthrie, A. J. Pond, M. E. Grzelak, X. Xu, W. A. Korfmacher, D. Tulshian, E. M. Parker, G. A. Hi

Journal:

Psychopharmacology

Year:

2005

Language:

english

File:

PDF, 248 KB

english, 2005

28

Potent, selective, and orally active adenosine A2A receptor antagonists: Arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines

Bernard R. Neustadt, Jinsong Hao, Neil Lindo, William J. Greenlee, Andrew W. Stamford, Deen Tulshian, Ennio Ongini, John Hunter, Angela Monopoli, Rosalia Bertorelli, Carolyn Foster, Leyla Arik, Jean L

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 170 KB

english, 2007

29

Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242

I Mancini, R Brusa, G Quadrato, C Foglia, P Scandroglio, LS Silverman, D Tulshian, A Reggiani, M Beltramo

Journal:

British Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 352 KB

english, 2009

30

Nociceptin inhibits cough in the guinea-pig by activation of ORL1 receptors

Robbie L McLeod, Leonard E Parra, Jennifer C Mutter, Christine H Erickson, Galen J Carey, Deen B Tulshian, Ahmad B Fawzi, April Smith-Torhan, Robert W Egan, Francis M Cuss, John A Hey

Journal:

British Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 118 KB

english, 2001

31

Routes From “Triacetyl Glucal” to 6-Deoxy-Hex-2-Enopyranosides

Fraser-reid, Bert, Kelly, David R., Tulshian, Deen B., Ravi, Prasad S.

Journal:

Journal of Carbohydrate Chemistry

Year:

1983

Language:

english

File:

PDF, 338 KB

english, 1983

32

ChemInform Abstract: A Synthesis of Dihydroimidazo[5,1-a]isoquinolines Using a Sequential Ugi—Bischler—Napieralski Reaction Sequence.

W. Michael Seganish, Ana Bercovici, Ginny D. Ho, Hubert J. J. Loozen, Cornelis M. Timmers, Deen Tulshian

Journal:

Year:

2012

File:

PDF, 35 KB

2012

33

Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: Part 2

Stephanie Brumfield, Julius J. Matasi, Deen Tulshian, Michael Czarniecki, William Greenlee, Charles Garlisi, Hongchen Qiu, Kristine Devito, Shu-Cheng Chen, Yongliang Sun, Rosalia Bertorelli, Justin An

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 470 KB

english, 2011

34

Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia

Shu-Wei Yang, Jennifer Smotryski, William T. McElroy, Zheng Tan, Ginny Ho, Deen Tulshian, William J. Greenlee, Mario Guzzi, Xiaoping Zhang, Deborra Mullins, Li Xiao, Alan Hruza, Tze-Ming Chan, Diane R

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 977 KB

english, 2012

35

The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia

Ginny D. Ho, Shu-Wei Yang, Jennifer Smotryski, Ana Bercovici, Terry Nechuta, Elizabeth M. Smith, William McElroy, Zheng Tan, Deen Tulshian, Brian McKittrick, William J. Greenlee, Alan Hruza, Li Xiao,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 932 KB

english, 2012

36

Pyrazoloquinolines as PDE10A inhibitors: Discovery of a tool compound

William T. McElroy, Zheng Tan, Kallol Basu, Shu-Wei Yang, Jennifer Smotryski, Ginny D. Ho, Deen Tulshian, William J. Greenlee, Deborra Mullins, Mario Guzzi, Xiaoping Zhang, Carina Bleickardt, Robert H

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 573 KB

english, 2012

37

Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain

Chad E. Bennett, Duane A. Burnett, William J. Greenlee, Chad E. Knutson, Peter Korakas, Cheng Li, Deen Tulshian, Wen-Lian Wu, Rosalia Bertorelli, Silva Fredduzzi, Mariagrazia Grilli, Gianluca Lozza, A

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 877 KB

english, 2012

38

The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia

Ginny D. Ho, W. Michael Seganish, Ana Bercovici, Deen Tulshian, William J. Greenlee, Rachel Van Rijn, Alan Hruza, Li Xiao, Diane Rindgen, Deborra Mullins, Mario Guzzi, Xiaoping Zhang, Carina Bleickard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.39 MB

english, 2012

39

Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models

Robbie L. McLeod, Deen B. Tulshian, Donald C. Bolser, Geoffrey B. Varty, Marco Baptista, Xiomara Fernandez, Leonard E. Parra, Jennifer C. Zimmer, Christine H. Erickson, Ginny D. Ho, Yanlin Jia, Fay W.

Journal:

European Journal of Pharmacology

Year:

2010

Language:

english

File:

PDF, 942 KB

english, 2010

40

A synthesis of dihydroimidazo[5,1-a]isoquinolines using a sequential Ugi–Bischler–Napieralski reaction sequence

W. Michael Seganish, Ana Bercovici, Ginny D. Ho, Hubert J.J. Loozen, Cornelis M. Timmers, Deen Tulshian

Journal:

Tetrahedron Letters

Year:

2012

Language:

english

File:

PDF, 377 KB

english, 2012

41

Nociceptin inhibits capsaicin-induced bronchoconstriction in isolated guinea pig lung

Michel R Corboz, Maria A Rivelli, Robert W Egan, Deen Tulshian, Julius Matasi, Ahmad B Fawzi, Lawrence Benbow, April Smith-Torhan, Hongtao Zhang, John A Hey

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 139 KB

english, 2000

42

Antitussive action of nociceptin in the cat

Donald C Bolser, Robbie L McLeod, Deen B Tulshian, John A Hey

Journal:

European Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 75 KB

english, 2001

43

Synthesis and phosphodiesterase activity of carboxylic acid mimetics of cyclic guanosine 3',5'-monophosphate

Tulshian, Deen, Czarniecki, Michael, Doll, Ronald J., Ahn, Ho Sam

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 1.88 MB

english, 1993

44

Antitussive Effect of Nociceptin/Orphanin FQ in Experimental Cough Models

Robbie L. McLeod, Donald C. Bolser, Yanlin Jia, Leonard E. Parra, Jennifer C. Mutter, Xin Wang, Deen B. Tulshian, Robert W. Egan, John A. Hey

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2002

Language:

english

File:

PDF, 102 KB

english, 2002

45

Out-of-ring Claisen rearrangements are highly stereoselective in pyranoses: routes to gem-dialkylated sugars

Tulshian, Deen Bandhu, Tsang, Raymond, Fraser-Reid, Bert

Journal:

Journal of Organic Chemistry

Year:

1984

Language:

english

File:

PDF, 1.20 MB

english, 1984

46

Discovery of Orally Active 3-Pyridinyl-tropane As a Potent Nociceptin Receptor Agonist for the Management of Cough

Yang, Shu-Wei, Ho, Ginny, Tulshian, Deen, Greenlee, William J., Anthes, John, Fernandez, Xiomara, McLeod, Robbie L., Hey, John A., Xu, Xiaoying

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 858 KB

english, 2009

47

Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain

Brumfield, Stephanie, Korakas, Peter, Silverman, Lisa S., Tulshian, Deen, Matasi, Julius J., Qiang, Li, Bennett, Chad E., Burnett, Duane A., Greenlee, William J., Knutson, Chad E., Wu, Wen-Lian, Sasik

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 3.62 MB

english, 2012

48

GLASGOW SOUTHERN MEDICAL SOCIETY.

Brumfield, Stephanie, Korakas, Peter, Silverman, Lisa S., Tulshian, Deen, Matasi, Julius J., Qiang, Li, Bennett, Chad E., Burnett, Duane A., Greenlee, William J., Knutson, Chad E., Wu, Wen-Lian, Sasik

Journal:

Year:

1900

Language:

english

File:

PDF, 1.03 MB

english, 1900

49

Bioavailable pyrrolo-benzo-1,4-diazines as Nav1.7 sodium channel blockers for the treatment of pain

Yang, Shu-Wei, Ho, Ginny D., Tulshian, Deen, Bercovici, Ana, Tan, Zheng, Hanisak, Jennifer, Brumfield, Stephanie, Matasi, Julius, Sun, Xianfeng, Sakwa, Samuel A., Herr, R. Jason, Zhou, Xiaoping, Brida

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.70 MB

english, 2014

50

Discovery of pyrrolo-benzo-1,4-diazines as potent Nav1.7 sodium channel blockers

Ho, Ginny D., Tulshian, Deen, Bercovici, Ana, Tan, Zheng, Hanisak, Jennifer, Brumfield, Stephanie, Matasi, Julius, Heap, Charles R., Earley, William G., Courneya, Brandy, Jason Herr, R., Zhou, Xiaopin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 901 KB

english, 2014

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